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KMID : 1123920100240040598
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Korean Journal of Oriental Physiology and Pathology
2010 Volume.24 No. 4 p.598 ~ p.601
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Effects of the Combined-Preparation of Germinated Brown Rice, Cultured Mountain Ginseng and Longanae Arillus on Pentobarbital-induced Sleeping Time
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Oh Suk-Heung
Oh Ki-Wan
Cho Hyoung-Kwon
Eun Jae-Soon
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Abstract
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This experiment was performed to investigate whether the combined-preparation of water extracts of germinated brown rice (WGR), water extracts of cultured mountain ginseng (WCG) and 70% ethanol extracts of Longanae Arillus (ELA) has hypnotic effects and/or enhances pentobarbital-induced sleep behaviors through the GABAergic system. The combined-preparation of WGR and WCG reduced sleep latency and prolonged sleep time induced by pentobarbital. ELA also reduced sleep latency and prolonged sleep time induced by pentobarbital. However, WGR or WCG itself did not induce sleep. The combined-preparation of WGR, WCG and ELA strongly reduced sleep latency and prolonged sleep time via chloride influx into primary cultured cerebellar granule cells. In conclusion, the combined-preparation of WGR, WCG and ELA augments pentobarbital-induced sleep behaviors through the modification of GABAergic system.
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KEYWORD
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germinated brown rice, cultured mountain ginseng, Longanae arillus, sleep time, chloride ion
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